What we do

Welcome to the Kingshill Research Centre (Swindon), a clinical trials research unit based at the Victoria Centre on the Great Western Hospital site in Swindon, Wiltshire. The story of the Kingshill Research Centre began in 1994 when world-renowned Old-Age Psychiatrist and key opinion leader, Dr Roger Bullock, established a team in Swindon to carry out clinical trials for dementia drugs. Since then, the unit has built an international reputation for dementia trials and is renowned for its work with Alzheimer's Disease studies.

For more information, please see a list of our clinical trials and studies in our Kingshill Research Centre Studies section.

We are an experienced team led by our Principal Investigator (PI) Dr Sabarigirivasan Muthukrishnan. The team also includes Sub-Investigators (sub-I), three nurses, a psychologist and administration staff.

The Kingshill Research Centre was involved in trials for the Alzheimer's drugs that are presently licensed for use in the NHS. New drugs must successfully complete a clinical trial process involving three phases before being approved for use in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA).

  • Phase 1 trials: the first stage of human testing, often involving healthy volunteers.
  • Phase 2 trials: this involves up to a few hundred volunteers who have the condition the drug is designed to treat. Studies in phase 2 provide further information about safety and help to determine the best dosage of a drug. They are generally too small to provide clear evidence about a treatment's benefit.
  • Phase 3 trials: this involves several hundred to thousands of volunteers, often at study sites worldwide. They provide the chief evidence for safety and effectiveness that the MHRA will analyse before approving a drug.

Most of our trials involve testing an oral drug and are mostly phase 2 and 3 trials. We work with all clinical services across the Trust and we welcome self-referrals for all our studies.Visit our current studies section for details of the trials we are running.

The Kingshill Research Centre has worked with major pharmaceutical companies on successful trials. If you are interested in talking to us, you can contact us by:

Phone: 01793 327954

Email: awp.kingshillresearch@nhs.net

If you are a service user or carer interested in taking part in one of our trials, please see our section on taking part in clinical trials


Our clinical trials help to test how safe and effective new drugs are. They also provide data on how combinations of new and existing drugs work for other conditions. Our research is carried out after strict ethical approval and under strict ethical guidelines.

Taking part in a trial

Taking part in a clinical trial could involve:

  • attending the Kingshill Research Centre regularly depending on the trial visit schedule.
  • taking a tablet/pill or visiting us monthly for an infusion of the trial drug. An infusion would be given intravenously (through a vein).
  • completing cognitive assessments (which relate to your thought processes, ability and understanding) and carer assessments with a study partner. We use these to monitor your capabilities during the trial.
  • monitoring your general health, using methods such as blood test, ECG to check your heart’s rhythm and electrical activity, and MRI and PET scans which use a medical imaging machine to scan your brain and to produce images.

There are no guaranteed benefits from clinical trials because we do not know exactly how effective a drug will be for any particular individual, which is why a trial is carried out. However, being on a trial can:

  • give you early access to new medications before license.
  • allow close monitoring of your own condition by our team.
  • create a feeling of satisfaction; the research you have been involved in might help others in the future.

What to do if you want to take part

You can find out if we need anyone with your condition, situation or experience for a trial that we are recruiting for. For more information, please see a list of our clinical trials and studies in our Kingshill Research Centre Studies section.